DEVELOPMENT AND EVALUATION OF HERBO SYNTHETICGEL: A NOVEL TREATMENT FOR PSORIASIS
AbstractBackground: Psoriasis is an immune-mediated inflammatory disease characterized by excessive growth and abnormal differentiation of keratinocytes. Objective: In the present research work, an attempt has been made to formulate and evaluate gel containing cyclosporine, aloe vera and tree tea oil. Methods: The gel was prepared by a conventional method and evaluated for various parameters viz., physical appearance, pH, drug content, viscosity, spreadability and in-vitro diffusion studies, In-vitro skin retention studies and stability studies. The prepared optimized gel was further compared with marketed formulation; all the formulations were good in appearance and had good homogeneity. Results: The optimized gel is shown spreadability co-efficient is 5.8 g cm/sec. The gel has shown 95 ± 0.32% releases in 6 h when evaluated for in-vitro diffusion studies. The biological evaluation of the optimized gel has shown 47.98 % drug activity, indicating good efficacy of the formulation against psoriasis. Conclusion: In conclusion, the prepared optimized gel has shown good spreading co-efficient and stability and can be effective for psoriasis as compared to available gel in the market.
Article Information
17
4745-4752
722 KB
640
English
IJPSR
Vinay Pandit * , Anurag Kumar, Tarun Kumar Sharma, CPS Verma and Shiv Kumar Kushawaha
Department of Pharmaceutics, Kathog, Distt, Kangra, Himachal Pradesh, India.
vinay2121@gmail.com
03 August 2020
27 July 2021
28 July 2021
10.13040/IJPSR.0975-8232.12(9).4745-52
01 September 2021
Download