DEVELOPMENT AND EVALUATION OF HYDROCORTISONE-LOADED NIOSOMAL GEL
AbstractObjective: The present research work was to formulate optimize and evaluate hydrocortisone-loaded niosomal gel for the management of rheumatoid arthritis. Method: Niosomal gel was successfully prepared by lipid-thin film hydration process and optimized by using 23 full factorial designs using three independent variables (tween 80 concentration, cholesterol concentration, and sonication time) and three dependent variables (cumulative drug release, mean particle size and entrapment efficiency). The effect of all variables was assessed by response surface methodology. Results: The prepared formulations were evaluated in terms of particle size, in-vitro drug release, encapsulation efficiency, zeta potential, viscosity, and spreadability. Based on response surface methodology, S6 formulation was found to be the best formulation with entrapment efficiency of 92.27%, in-vitro drug release of 75.61% in 8 hrs, and mean particle diameter of 121.58 nm. The stability studies indicated that all the formulations are stable as none exhibited significant drug content change over time. Conclusion: The study indicated the successful development of hydrocortisone-loaded niosomal gels with improved penetration, good homogeneity, and enhancement of duration of action. It can thus be concluded that the developed gel could be an effective treatment for rheumatoid arthritis.
Article Information
23
1265-1272
1703 KB
303
English
IJPSR
V. Choudhary, D. Rani *, N. Ghosh and M. Kaushik
Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India.
deepikapharma94@gmail.com
28 June 2022
27 August 2022
31 August 2022
10.13040/IJPSR.0975-8232.14(3).1265-72
01 March 2023