DEVELOPMENT AND EVALUATION OF POLY-HERBAL FORMULATION FOR ESCHAR REMOVAL AND WOUND HEALING

The objective of this work was to create a polyherbal formulation and evaluate its antibacterial and wound-healing properties in an in-vitro setting. Physicochemical properties of a topical polyherbal formulation were assessed with the chitosan, gelatin, neem, pectin, honey, and aloe vera were combined in different proportions. Polyherbal formulations were assessed for their tensile strength, swelling behavior, moisture retention, microbial penetration, honey release, pH, folding endurance, thickness, water vapor transmission in the prepared formulation. In-vitro activity revealed that F5 formulation had the better wound healing potential as compared to F4 and F3. Thus, we can conclude that enhanced dressings with good wound healing capabilities can lead to new possibilities in the treatment of wound healing related to burns. The outcome of this investigation indicates that the film made with various herbs and 5.4 ml of honey meets all the specifications for wound dressings, including thickness, weight, and folding endurance. The polyherbal formulation has tensile strength of 26N/mm², moisture uptake of 17.14 ± 1.12 to 26.7 ± 2.17%, and swelling behavior of 85.38. Its antibacterial properties against S. aureus and E. coli, which also prevent microbes from migrating to the wound bed from the surrounding environment. The results of the microbiological penetration test were positive. The mechanisms behind wound healing will be more clearly defined by additional research on polyherbal formulation.