DEVELOPMENT AND EVALUATION OF SILVER SULPHADIAZINE LOADED NANOFIBROUS SCAFFOLD FOR WOUND DRESSING APPLICATIONS

Electrospinning is the fiber-forming process using an electric field where electrostatic forces are employed. By this process, continuous nanofibers range from 0.01 to 10 micrometers can be obtained. Nanofibers produced by the electrospinning technique has application in various fields such as tissue engineering, wound dressing, filtration, protective clothing, drug delivery, and sensor applications. This study aimed to develop a novel bio medicated nanofibrous scaffold for wound dressing applications. Nanofiber of polyvinyl alcohol and sodium alginate loaded with silver sulphadiazine were successfully prepared by the electrospinning method. The formulations were subjected to various physicochemical evaluations such as weight variation, surface pH, folding endurance, moisture evaluation studies, biodegradability, and in vitro drug release studies. All the prepared nanofibers were found to be transparent, flexible with a smooth surface. The physicochemical characteristics of Medicated nanofibers were satisfactory concerning weight variation, surface pH, folding endurance, moisture loss, and moisture uptake studies. The drug entrapment was in the acceptable range for all the formulations, indicating a uniform distribution of the drug. Nanofibers prepared using sodium alginate, and polyvinyl alcohol showed satisfactory biodegradability. Thus, a polyvinyl alcohol-SA wound dressing system containing silver sulphadiazine could be a good candidate in wound care.