DEVELOPMENT AND EVALUATION OF TASTE MASKED ORODISPERSIBLE TABLET OF OFLOXACIN

Ofloxacin is an antibacterial agent used to treat infections. It is extremely bitter in taste and taste should be masked to formulate it in a palatable form.  The  purpose  of  present  research  work  was  to formulate tasteless complexes of  ofloxacin with  indion 204  ion  exchange  resin. The drug  loading onto ion-exchange resin  was optimized  for  mixing  time,   activation,  effect  of  pH,  mode  of  mixing,  ratio  of  drug: resin  and  temperature. The resinate was evaluated for taste masking and   in vitro   drug release.  DSC analysis study supported complex formation. ofloxacin- indion 204  complex of ratio  1:1.5 was  developed  into   orodispersible tablet   using different  superdisintegrants  with  varying  concentration  and  was evaluated  for  weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time and dissolution and was found superior over conventional formulation. The F5 batch with disintegration time 19.33 Sec ±3.78 and dissolution within 45 minutes 89.642±2.20 was selected as optimized formulation. By an appropriate selection and combination of excipients, it was possible to obtain orodispersible and taste masked tablets. Batch F5 Contains, Ofloxacin: Indion-204 complex (1:1.5 Ratio, Sodium starch Glycolate, Crosspovidone, Crosscarmellose sodium, NaHCO_3, Citric acid, Mannitol, Talc.