DEVELOPMENT AND METHOD VALIDATION USING HPLC FOR ASSAY OF ZIPRASIDONE CAPSULEAbstract
A reverse phase HPLC method is described for the determination of Ziprasidone HCl capsule by analytical method. Chromatography was carried out on an ODS C18 column using a mixture of buffer solution, acetonitrile and methanol (45: 40: 15v/v/v) as the mobile phase at a flow rate of 1.5mL/min. Detection was carried out at 230nm. The retention time of the drug was 7-9 min. The method produced linear responses in the concentration range of 50-150µg/mL of Ziprasidone .The method was found to be applicable for determination of the drug in capsules.
M. Gnana Ruba Priya*, M. Karikalan, S. Asadulla, S. Rajesh, J. Siva Rama Krishna and S. Vijay Sridhar
Department of Pharmaceutical Chemistry, CNK Reddy College of Pharmacy, Bangalore-91, Karnataka, India
18 May, 2011
18 July, 2011
23 August, 2011
01 September, 2011