DEVELOPMENT AND VALIDATION OF STABILITY INDICATING SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORMAbstract
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage purity was found to be 99.94% and an excellent mean recovery (98.65%-100.7%). The method was validated statistically and it can be employed for the routine analysis of Rizatriptan benzoate in marketed formulations.
Uttam Prasad Panigrahy* and M. Divya Swetha
Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Secunderabad, Andhra Pradesh, India
25 May, 2013
30 June, 2013
26 September, 2013
01 October, 2013