DEVELOPMENT CHARACTERIZATION OPTIMIZATION OF ETHOSOME CONTAINING DULOXETINE FOR TRANSDERMAL DELIVERYAbstract
The present investigation deals with the development of duloxetine ethosome then loading into the transdermal patch to impart lower drug side effect, enhanced bioavailability, avoiding first-pass metabolism. 32 factorial design was applied to optimize the formulation. Ethanol (X1) and Phospholipid (X2) were taken as independent variable, Responses are vesicle size (Y2), entrapment efficiency (Y1). Optimum desirability was identified and, an optimized formulation was prepared, characterized and loaded into transdermal patch. The transdermal patch was evaluated for drug content, thickness, folding endurance. Ex-vivo permeation study for the prepared patch was conducted and, the permeation parameters and drug permeation mechanism were identified. The percent of alcohol was significantly affecting all the studied responses while the other factors and their interaction effects were varied in their effects on each response. The optimized ethosomes formulation showed observed values for Y2, Y1 of 161 nm and 98.79% respectively. Ex-vivo permeation of films loaded with optimized ethosomal formulation was superior to that of the corresponding pure drug transdermal Patches.
E. Kumar * and C. N. Patra
Department of Pharmaceutics, University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, Telangana, India.
24 April 2019
28 August 2019
01 September 2019
01 February 2020