DEVELOPMENT OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF AMOXICILLIN AND CARBOCISTEINE IN SOLID DOSAGE FORM BY RP-HPLCAbstract
Pharmaceutical analysis is the application of principles of analytical chemistry to drug analysis. The analytical chemistry is the science of developing accurate, precise, and sensitive methods for determining the composition of materials in terms of elements or compounds which they contain. Quality means confirming specifications and standards, and it is never an accident; it is a result of intelligent efforts. Quality assurance influences the quality of the product and plays a central role in assuring the quality, safety, purity, and effectiveness of the drug products. Estimation of amoxicillin and carbocisteine in their combined dosage form were done. Official books also do not provide methods for simultaneous analysis. Most of the methods available for the analysis of active ingredients of such formulations are applicable only after prior separation, which makes it tedious and time-consuming and also a costly affair. In experimental work trials of various mobile phases, Analysis of laboratory mixture by proposed method carried out. The calibration curve was found to be linear in the concentration range of 5-25 µg/ml for Carbocisteine and 10-50 µg/ml for Amoxicillin, respectively. The application of the proposed method for the estimation of both drugs in marketed formulation took place. Validation parameters studied in that recovery studies for combinations were found to be within the acceptable limit.
S. S. Mankar * and M. Younas
Department of Quality Assurance, Agnihotri College of Pharmacy, Wardha, Maharashtra, India.
28 April 2019
28 February 2020
19 March 2020
01 April 2020