DEVELOPMENT OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CEFTRIAXONE SODIUM IN DIFFERENT BRANDS OF PHARMACEUTICAL PREPARATION INVOLVING DIAZOTIZATION
AbstractA simple, precise, and robust spectrophotometric method for the determination of Ceftriaxone sodium has been investigated and validated. The proposed chemical reaction involved involves the reaction primary amine of Ceftriaxone sodium with nitrite solution in acidic medium to form a diazotized product followed by the reaction of the diazotized product with suitable coupling reagent to obtained a colored product. Ceftriaxone sodium has shown λmax 510nm with absorbance of 0.126. The method obeys Beer Lambert law at concentration range of 1-20ppm by showing linearity curve between absorbance and concentration. In the method detection limits was observed 0.726ppm with quantification limit of 2.42ppm and standard deviation of 0.242. In the present work an attempt was made to develop a simple, less expensive and more reliable method for the determination of Ceftriaxone sodium in pure and pharmaceutical preparations
Article Information
25
5164-73
422
1537
English
IJPSR
Sajjad Ali Ilyas, Muhammad Imran *, Naresh Kumar, Jasmin Shah, M. Rasul Jan, Zohra Kousar and Muhammad Aslam
Department of Chemistry, University of Azad Jammu & Kashmir, Muzaffarabad, Pakistan
imjaral@yahoo.com
10 May, 2015
25 September, 2015
20 November, 2015
10.13040/IJPSR.0975-8232.6(12).5164-73
01 December, 2015
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