DIFFERENTIAL SCANNING CALORIMETRY AND INFRARED SPECTROMETRY METHODS FOR THE QUANTIFICATION OF ETHAMBUTOL HYDROCHLORIDE IN ORAL DOSAGE FORMS
AbstractA new, simple, and sensitive differential scanning calorimetry and infrared spectrophotometric technique was developed to estimate ethambutol hydrochloride in tablet dosage form. In the first method the concentration range of ethambutol hydrochloride was discovered to be 0.5 mg to 2.0 mg using differential scanning calorimetry (DSC), with the peak region of an exothermic thermogram at 75.8 °C and a continuous heating rate of 5 °K min-1. Second method which involves the measurement of ethambutol hydrochloride by Infra Red (IR) spectroscopy, the concentration range was determined to be 1.0 mg to 2.5 mg. The correlation coefficients for these techniques were determined to be 0.999 and 0.9919 for both DSC and IR methods respectively. The analytical results were statistically validated by the ANOVA technique and recovery trials. The recovery trials show no influence from other chemicals in the formulation. As a result, these two procedures are easy, precise, accurate and specific, and they might be employed for regular analysis.
Article Information
19
2058-2063
600 KB
145
English
IJPSR
N. Delhiraj * and A. M. Sekar
Department of Pharmaceutical Analysis, School of Pharmacy, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.
pharmaraj1981@gmail.com
21 January 2024
15 March 2024
16 April 2024
10.13040/IJPSR.0975-8232.15(7).2058-63
01 July 2024
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