ECO-FRIENDLY AND COST-EFFECTIVE UV SPECTROSCOPY METHOD FOR THE ESTIMATION OF PREDNISOLONE SODIUM PHOSPHATE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Prednisolone Sodium Phosphate (PSP) is a steroidal anti-inflammatory or immune suppressive agent. It is a sodium salt of the phosphoester of the glucocorticoid prednisolone. It is freely soluble in water; soluble in methanol; slightly soluble in alcohol and in chloroform; and very slightly soluble in acetone and in dioxane.A simple spectrophotometric method was developed for the determination of Prednisolone Sodium Phosphate in Pharmaceutical   tablet   dosage form. PSP exhibiting λ max at 246nm in solvent media 100% water and obeyed linearity in the concentration range of 2 to 12µg and exhibited good correlation coefficient (R²=0.999). This method was successfully applied to the determination of PSP content in four different marketed brands from local market and the results were in good agreement with the label claims. The percentage recovery was found to be 99.80±0.238. The sample solution was stable up to 10 hours.The method was validated statistically and studies for linearity, precision, repeatability, and reproducibility. Various methods for analysis of the Prednisolone Sodium Phosphate are available but are time consuming and expensive. But here developed method is new, pricise, accurate, simple, safe and stability indicating. Furthermore it was safe for operator, environmently friendly and economical in terms of cost of chemicals and waste management. Thus, this method is not only suits for routine pharmaceutical quality control analysis work, but also presents prototype for the development and utilization of greener analytical procedures in which an environmental impact is concerened. The obtained results proved the method can be employed for the routine analysis of prednisolone sodium phosphate.