EFFECT OF DRUG RELEASE ON ALBENDAZOLE CHEWABLE TABLETS BY USING DIFFERENT FORMULATION TECHNIQUESAbstract
In this research study, the effect of drug release of albendazole chewable tablets has been determined. The drug release is calculated by using the disintegration process, which is directly related to the hardness of tablets. The tablets are prepared by using three types of granulating methods are non-aqueous granulation, aqueous granulation, and direct compression. The tablets are evaluated by calculating different parameters such as hardness, friability, disintegration, assay, and in-vitro dissolution studies. The % drug release was determined by using U V spectrophotometry. In the three techniques and the non-aqueous granulation was the better technique for the formulation of tablets, dissolution rate, and % drug release other than aqueous granulation and direct compression method. So by this, we can say the non- aqueous technique gives immediate drug release by which the drug can be used at the time of emergency and gives relief to the patient, and the chewable tablets can use for the children easily. The present study was to prepare the chewable albendazole tablets by granulating techniques, i.e., non aqueous granulation, aqueous granulation, and direct compression methods and to compare the drug release profiles of the tablets with the marketed product.
K. S. C. Sharma, Y. K. Kumar * and K. R. Reddy
SSJ College of Pharmacy, Vattinagulapally, Hyderabad, Andhra Pradesh, India.
19 March 2014
19 May 2014
09 July 2014
01 October 2014