EFFECT OF GRANULATION TECHNIQUE AND DRUG-POLYMER RATIO ON RELEASE KINETICS OF GLICLAZIDE FROM METHOCEL K15M CR MATRIX TABLET

The effect of different percentages of a hydrophilic polymer and impact of granulation technique on the release profile of gliclazide from matrix system was investigated. Matrix tablets of Gliclazide were prepared by both direct compression and wet granulation process using METHOCEL K15M CR. Release kinetics of Gliclazide matrix tablets were determined using USP paddle method at Phosphate buffer (pH 7.4) and conducting for 10 hours. Statistically significant differences were found among the drug release profile from different polymeric concentration and granulation process. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer model. It’s found that at lower concentration of polymer (15%) most of the formulation tends to Higuchi release kinetics and at higher concentration (30%) best fit with Zero order release kinetics.   Higher polymeric content (30%) in the matrix decreased the rate of the drug due to increased tortuosity and decreased porosity. At lower polymeric level (15%) the rate of drug release was elevated. In this study effect of granulation process on drug release also examined and found that wet granulation extend the release more than that of the direct compression technique.