EFFECT OF NIMESULIDE IN REVERSING RESERPINE INDUCED DEPRESSION IN MICE

Aim: To demonstrate the effect of Nimesulide in reversing Reserpine induced depression in mice. Materials and Methods: This test was done using 20-25gm of healthy albino mice of either sex in the Department of Pharmacology of Gauhati medical college. They were housed in standard laboratory condition at 25ºC and fed on standard diet and water ad libitum. Five groups were selected each containing six mice. The groups were Group I (Normal Control), Group II (Disease Control), Group III  (Fluoxetine 10mg/kg i.p),Group IV ( Nimesulide 2.5mg/kg i,p) and  Group V (Nimesulide 5mg/kg i.p)Reserpine (2mg/kg i.p) was used to induce depression in all the groups except the Normal Control. After 24 hours, the standard and test drugs were given and the mice were subjected to tail suspension test (TST) after 30 mins and forced swim test (FST) after 1 hour of injecting the drugs. Result: Mean±SEM values were calculated for each group. The data were analyzed using ANOVA and post analysis was done by Dunnett’s test. Results were found to be significant (p<.05). The period of immobility was found to be reduced in the test groups in a dose dependent manner as compared to the Disease Control .However, the episodes and the duration of immobility was minimum in the Standard group. Conclusion: Nimesulide has been found to be effective in reversing reserpine induced depression in mice.