EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS ON RESERPINE INDUCED PARKINSONISM IN RATS

Parkinson’s disease is a chronic progressive neuro-degenerative disease caused by selective degeneration of dopaminergic neurons in the dense part of the substantia nigra pars compacta. It is characterized by motor and non-motor symptoms, especially the gradual reduction of postural symptoms, instability, tremor and memory impairment, local neuron loss, which mainly occurs in the substantia nigra. The current study evaluated the effects of non-steroidal anti-inflammatory drugs on reserpine-induced Parkinsonism experimental model. Subcutaneous injection of reserpine (1 mg/kg) was given to all rats for 5 days to induce Parkinson’s like symptoms; syndopa (10 mg/kg) was used as standard, and aspirin (60 mg/kg), celecoxib (20 mg/kg) and Indomethacin (20 mg/kg) were given orally and after 60 min of reserpine were administered. Behavioural and neurochemical parameter assays were done for dopamine, acetylcholinesterase, lipid peroxidation and other antioxidant enzymes. Our results showed reserpine significantly induced locomotor deficits and oxidation in the brain in a period of 5 days. Celecoxib, aspirin and Indomethacin showed significant improvement in locomotor behaviour and showed neuroprotective activity by reducing the oxidative status in the brain and increasing the dopamine content. Therefore, the present study showed the protective effects of Celecoxib, aspirin and Indomethacin against reserpine induced in rats.