EFFECT OF POLYMERIC RATIO AND PORE FORMERS ON SUPER POROUS HYDROGEL OF AMOXYCILLIN TRIHYDRATE
AbstractThe work aimed to prepare super porous hydrogels (SPHs) of Amoxicillin trihydrate to release the drug in a sustained manner in the gastric environment and study the polymeric ratio and pore effect formers on the physicomechanical properties and drug release kinetics of the formulations. Fourier Transform Infra-Red (FTIR) studies were done to check the compatibility of the drug with the polymers. The super porous hydrogel formulations were prepared in two batches (A and B) using sodium chloride and sodium bicarbonate as pore formers, respectively. Scanning Electron Microscopy observed the structural morphology of hydrogel. The presence of a large number of pores with sizes ranging from 1 to 10 μm was revealed, confirming the formation of a super porous hydrogel. As dictated by in-vitro dissolution data, the increases in the polymer concentration of HPMC K4M progressively retards and prolongs the drug release; however, no significant change in the effect was observed among NaCl and NaHCO3 pore formers in the super porous hydrogel. The drug release data were fitted into different kinetic models and were found to be best suited by Higuchi and Korsmeyer-Peppas models. Among the eight batches, drug release from is fully governed by quasi-Fickian diffusion (n < 0.45).
Article Information
20
1208-1217
1105 KB
361
English
IJPSR
Sayantan Bhattacharya *, Gopa Roy Biswas and Sutapa Biswas Majee
Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata- Group of Institutions, 124 B L Saha Road, Kolkata, West Bengal, India.
sayantanb35@gmail.com
10 June 2021
16 July 2021
17 July 2021
10.13040/IJPSR.0975-8232.13(3).1208-17
01 March 2022