EFFECT OF PROCESSING AND POLYMER VARIABLES ON INVITRO RELEASE OF METOPROLOL SUCCINATE EXTENDED RELEASE TABLETSAbstract
The present study was aimed to develop an extended release tablet of Metoprolol Succinate for the treatment of hypertension. Four extended release formulations F1-F4 were developed using varying proportions of Hydroxyl propyl methyl cellulose K100M, Sodium carboxy methyl cellulose and Eudragit L30 D55 by wet granulation. Five extended release formulations F5-F9 containing HPMC K100M and HPMC 5cps in varying concentration were developed by direct compression. The physico-chemical and in-vitro release characteristics of all the formulations were investigated and compared. Two formulations, F7 and F8 have shown not more 25% drug release in 1st h, 20-40% drug release at 4th h, 40-60% drug release at 8th h and not less than 80% at 20th h and the release pattern conform with USP specification for 24 h extended release formulation. It can be conclusively stated that optimum concentration of HPMC K100M (58-65%) by direct compression method can yield an extended release of Metoprolol succinate for 24 hours.
N. N. Rajendran*, R. Natarajan and T. Sakthikumar
Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengodu, Namakkal – 637205, Tamil Nadu, India
06 August, 2011
04 October, 2011
02 December, 2011
01 December, 2011