EFFECT OF TRANS – ESTERIFICATION OF OIL ON NANOEMULSION GEL FOR TOPICAL DRUG DELIVERY

The research investigated the modification of nano-emulsion by using transesterfied soyabean oil, to enhanced solubility and diffusion of voriconazole. Ternary phase diagrams of soyabean oil, acid / base esters of soyabean oil, Tween 80: PEG 400 (S/CoS) and water were developed. Ester value of soyabean oil increased from 214.04 to 261.5mg KOH/1g for acid ester and 293.58mg KOH/1g for base ester confirmed transesterification. The modified nanoemulsion batches E₄, E₅, E_A4, E_A5, E_B2 and E_B3 showed thermodynamic stability. Nanoemulsion of Soyabean oil (E₃ and E₄), acid ester (E_A4 and E_A5)_, and base ester (E_B2 and E_B3) were selected for in-vitro drug diffusion studies. The globule size of batch E₄, E_A4 and E_B2 nanoemulsion was found to be 185.6, 162.8 and 115.4 nm, respectively. Zeta potential of batch E₄, E_A4, and E_B2 was observed -35, -27 and -9mV respectively. The in vitro release release profiles from the E₄, E_A4 and E_B2 batches of nanoemulsion gel were fitted into Peppas kinetic model. Moreover, ‘n’ value of batch E₄, E_A4, and E_B2 was 0.8844, 0.8284, 0.8475 non-fickian diffusion. The soyabean oil and soyabean acid ester oil nanoemulsion found to be stable and a promising vehicle to enhance the permeation of voriconazole for topical delivery.