EFFECT OF VITAMIN D ON THE OXIDATIVE STRESS PARAMETER (MDA) IN HYPOTHYROID PATIENTS

Background: Hypothyroidism is a metabolic disorder. Vitamin D is known to improve the impact of autoimmune diseases; hence, vitamin D supplements and adjuvant therapy can improve hormonal and metabolic imbalance along with oxidative stress. The study aims to determine the effect of Vitamin D on the oxidative stress parameter in hypothyroid patients compared to controls and hypothyroid subjects before and after vitamin D therapy. Methods: A prospective study of six months period was carried out among 120 subjects attending the General Medicine department. Age and gender-matched euthyroid controls (n=40) and patients who were newly diagnosed as hypothyroid (with increased serum TSH and or with decreased serum T₃ or T₄levels) were taken as cases (n=80). Serum TSH (mµ/L), T₃(pg/m), and T₄(ng/dl) levels were compared. Oxidative stress parameter (MDA) in hypothyroid patients is a tool to assess oxidative stress levels it was measured by using the Immunoassay method. Results: Oxidative stress parameter (MDA) in hypothyroid with and without vitamin D supplementation showed improvement indicating decreased levels in oxidative stress, along with statistical significance (p<0.001*). Oxidative stress parameter (MDA) in hypothyroid subjects as per serum TSH, T_3, and T₄ levels with and without Vitamin D supplementation showed significant improvement. Conclusion:  Prevalence of Hypothyroidism was displayed in females. An increase in oxidative stress parameter (MDA) level in hypothyroid subjects indicates an increase in oxidative stress levels in hypothyroid patients. Oxidative stress parameter (MDA) in hypothyroid subjects as per TSH, T₃ & T₄ levels with and without Vitamin D supplementation showed a significant change.