ELECTROCHEMICAL AND PHARMACOLOGICAL ANALYSIS OF CU-ATROPINE COMPLEX
AbstractThe Cu-Atropine complex may have potential applications in medicinal chemistry, as atropine is used in the treatment of certain medical conditions such as bradycardia and as a pre-anesthetic to decrease salivation. Additionally, the complexation of atropine with copper could potentially enhance its therapeutic effects or alter its pharmacokinetic properties. In the present study, the drug has been modified by complex formation with absolute methanol and concentrated sulphuric acid following standard procedures to increase its potency. IR spectra of Cu- atropine complex has taken. The analytical data indicates that a complex form of the drug, Cu-Atropine, is formed in a 1:1 ratio. To study the interaction between drugs and metal complexes, differential pulse polarography (DPP) has been used. These techniques are simple and cost-effective, making them suitable for qualitative and quantitative determination of active drug compounds. In a pharmacological study, modified atropine showed more potency compared to its parent drug.
Article Information
21
808-812
703 KB
227
English
IJPSR
Rakesh Choure * and S. K. Abdus Samim
Department of Chemistry, Government SSP College Waraseoni, Balaghat, Madhya Pradesh, India.
rchourechem@gmail.com
16 July 2023
10 November 2023
30 December 2023
10.13040/IJPSR.0975-8232.15(3).808-12
01 March 2024
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