ELECTROCHEMICAL BEHAVIOUR OF OMEPRAZOLE INTERACTING WITH MYCIN DERIVATIVES AND DOXYCYCLINE
AbstractThe interaction of omeprazole with different types of antibiotics was investigated in biological buffer at physiological pH=7.4 by using electrochemical (cyclic and linear sweep voltammetry) method. The reduction processes of omeprazole in the absence of and in the presence of azithromycin, clarithromycin, roxithromycin and doxycyclline are irreversible. Omeprazole interacts in solution with antibiotics structures by a predominantly electrostatic mechanism. From electrochemical data, The 1:2, 1:1, 1:1 and 1:2 complexes of azithromycin-omeprazole, clarithromycin-omeprazole, roxithromycin-omeprazole and doxycycline-omeprazole are formed with the binding constants β = 3.930 (±0.15), 0.985 (±0.02), 0.321 (±0.01) and 8.230 (±0.21) µM-1 respectively. The results show that, the binding affinity of omeprazole increases in the sequence: roxithromycin > clarithromycin > azithromycin > doxycycline.
Article Information
13
5183-5190
881KB
1741
English
IJPSR
Mahmoud A. Ghandour*, Ahmed Hassan and Hazim M.Ali
Chemistry Department, Faculty of Science, Assiut University, 71516, Assiut, Egypt.
ghandour0100@yahoo.com
12 May, 2014
23 July, 2014
20 August, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(12).5183-90
01 December 2014
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