EMERGING ROLE OF NUTRACEUTICALS IN THE MANAGEMENT OF HYPERTENSION: A SYSTEMATIC REVIEW
HTML Full TextEMERGING ROLE OF NUTRACEUTICALS IN THE MANAGEMENT OF HYPERTENSION: A SYSTEMATIC REVIEW
Rita Saini *, Anupriya Nautiyal and Shivanand Patil
Department of Pharmacy, Shree Dev Bhoomi Institute of Education, Science and Technology, Poundha, Dehradun, Uttarakhand, India.
ABSTRACT: Nutraceutical is a word obtained from Nutrition and Pharmaceuticals. Nutrients are a feed constituent that helps to support the life of human beings or animals. Pharmaceutical components are non-toxic food constituents, including prevention and treatment of disease. They commonly inhabit the disorders associated with oxidative stress, for instance, cardiovascular disease, Diabetes, and Hypertension. Nutraceuticals possess substantial importance because of their expected safety and possible nutritional and therapeutic effects. Hypertension is the most frequent risk factor for cardiovascular disease involving coronary heart disease and stroke. There is a crucial role in utilizing single and integral nutraceutical supplements, vitamins, antioxidants, and minerals in the treatment of hypertension. These food supplements rein huge demand because they are less toxic and have long life treatment with dietary food. We have done a face-to-face survey on 33 medical stores. The survey results found that the most demanding nutraceutical is Mactotal, and the least demanding nutraceuticals are Beryl tone and Allvell-Z graph seed extract. The survey study also shows a list of Nutraceuticals that are available in drug stores, including Mactotal, Omega fatty acids grape seed extract, Advanced BP support, Natural formula BP complex, Blood pressure formula, BP rescue, Cholbiome, Zeovita- 4G, Super B complex, Alpha-linolenic acid, Allvell-Z grape seed extract tablet, Antioxidant support, Vegifruit syrup, Beet juice and Beryl tone.
Keywords: Nutrition, Pharmaceutical, Hypertension, Cardiovascular disease, Diabetes
INTRODUCTION: Hypertension is not a disease it is a condition in which the force of blood against the artery walls is high. According to the 2017 American college of cardiology/ American heart association hypertension recommendations, hypertension is defined as systolic blood pressure above 130mmHg or diastolic blood pressure above 80mm Hg 1.
Usually, hypertension occurs when the blood pressure is above 140/90mm Hg, considering if the pressure is above 180/120mm Hg. The Hong Kong cardiovascular prevalence population investigated of healthy people randomly selected; the popularity of hypertension was below 2% in young subjects aged 25-34, but the prevalence rises to around 50% in those 65-75 years of age 2.
Research has recommended that the blood vessels naturally harden with age, losing their compliance. This may clarify why older people are more likely to modify high blood pressure 3. Hypertension disorders in pregnancy are among the most common medical complications, affecting 5% to 10% of pregnancies worldwide 4. The hypertension is divided into two types. Essential or primary hypertension when the condition has no known cause. When another condition causes hypertension, it is known as secondary hypertension 5. The factors of hypertension are shown in Table 1.
TABLE 1: FACTORS OF HYPERTENSION
Essential hypertension | Smoking |
Difficulty in breathing | Do not do exercise |
Arteriosclerosis | Are over 65 ages |
Cushing syndrome | Intake to much salt |
Medication of Hypertension: There are some medications which are used in the condition of hypertension:
- Antihypertensive Drug: Antihypertensive drugs may decrease cardiac output by either inhibiting myocardial contractility or reducing ventricular filling pressure 6.
- Non-Pharmacological Management of hypertension: It is a harmless treatment and helpful either to eliminate the drug requirement or reduce the dose. Non-pharmacological approaches to reducing blood pressure generally treat patients with diastolic blood pressure in the range of 90 to 95mmHg 7.
- Reduction of Body Weight: Obesity and hypertension are closely associated, and obese hypertensive may lower their blood pressure by losing weight regardless of a change in salt consumption 8.
- Sodium Restriction: Severe salt restriction will lower the blood pressure in most hospitalized hypertensive patients; this treatment method was advocated before developing effective antihypertensive drugs 9.
- Physical Exercise: Lake of physical activity is associated with a higher incidence of hypertension 10.
- Diet: Natural vegetables and dietary products contain high potassium levels, which lower the BP by increasing sodium excretion, decreasing sympathetic activity, and renin-angiotensin secretion 11.
Nutraceuticals: A nutraceuticals word combines ‘Nutrient’ and ‘Pharmaceutical’. According to AAFCO, 1996, ‘nutrient’ means a feed component in the form and at an extent that will assist or support of the life of a human being or animal occupy ‘nutraceutical’ means any non-toxic food constituent that has scientifically demonstrated health welfare, including the treatment of disease 12. Nutraceuticals are defined as-, according to Dr. Stephen De Felice- a “food, or parts of a food, that contribute medical or health welfare including the prevention and treatment of disease 13. It is also known as “Functional food”. The nutraceuticals components elaborated on the other components like dietary supplements, herbal components, vitamins, and nutrients 14.
Hippocrates stressed in the certified means, “Let food be the medicine and medicine be food”, concerning 2000years previously 15, 16. Nutraceutical components are the product in which the combination of nutrients and functional food are also used as medicine. Nutraceutical products are physiologically useful for the protection against in case of chronic disease, diabetes, cancer, high blood pressure, and Alzheimer's disease 17. The concept of nutraceuticals was started from the survey in U.K., Germany, and France, and its consumer then exercises hereditary factors to achieve an adequate health 18. Nutraceuticals are food derivatives that give therapeutic and health welfare, as well as the obstruction, Management, and treatment of disease, and involve a class the nutrient, encapsulated dietary additives, and frozen food.
Benefits of Nutraceuticals 19, 20:
FIG. 1: BENEFITS OF NUTRACEUTICALS
Nutraceuticals are physiologically health beneficial in many diseases like cancer, heart disease and the treatment of hypertension, diabetes, arthritis, and nutraceuticals may offer many benefits in human health 13, 14. Some benefits of nutraceuticals in human life are shown in Fig. 1.
- It increases the value of the diet.
- It may help us live longer.
- It helps us to avoid any particular long-term medical condition.
- It may be more natural than traditional medicine and helps produce less side effect in the body.
- It fulfills the deficiency of nutrients in our body.
- These are easily available in market and market and they are economically affordable.
Types of Nutraceuticals 21, 22: The nutraceuticals are mainly divided in two types:
- Traditional Nutraceuticals: This is the class which we get directly from nature without changing any natural form. Many constituents such as lycopene in tomatoes, saponins in soy are present and ingested for health benefits. Traditional nutraceuticals can be classified on the basis of:
(a) Chemical constituents: Based on chemical constituents the, nutraceuticals can divide into three types:
- Nutrients: Plant and animal products with a vitamin have many health welfares and are pleasant in curing heart, kidney, lung disease, etc. The nutrients elaborated the minerals, vitamins, and amino acids, with granted nutritional functions.
- Herbals: Nutraceuticals and herbs have a worthy influence on preventing many chronic diseases and producing healthier lives. Peppermint (Mentha piperita) carries several terpenoids, mainly menthol, a bioactive component and cures a cold and aches. Tannins contents of lavender assist issuing stress and blood pressure and are convenient for lung disorders.
- Phytochemicals: Phytochemicals are the nutrients based on plants with specific biological occupations that encourage human health. They are further mentioned as phytonutrients. Ex- Flavonoids, Phenolic acids, curcumin.
(b) Nutraceutical Enzyme: Some enzymes are obtained from plants, animals, and microbial origin. Enzymes are a crucial part of life, without which our body is authorized to come to an end of the function.
(c) Probiotic Microorganism: Probiotics manners ‘for life’. They are described as live microorganisms, which, when ingested in tolerable aggregates, consult a health effect on the host. Ex- Insulin.
- Non-traditional Nutraceuticals are food enhanced with additives or biotechnologically designed crops to improve the nutrients. Such as Rice and Broccoli are well off beta-carotene and vitamins. Non-traditional nutraceuticals are classified as follows:
- Fortified Nutraceuticals are enhanced with vitamins and minerals, generally at a range up to 100% of the dietary supplements gaining for the nutrient. These are nutraceuticals from agricultural procreation or added nutrients and constituents.
- Recombinant Nutraceuticals: Biotechnology implements have been well applied between an agitation process in several food substances such as cheese and bread to extract the enzyme convenient for providing essential nutrients at best level.
Nutraceuticals in Management of Cardiovascular disease Hypertension]: Cardiovascular diseases (CVD) are chronic diseases using disorders of the heart and blood vessels which generally include hypertension [high blood pressure], coronary heart disease [heart attack], stroke, etc. 23.
The nutraceuticals reduce the possibility of cardiovascular by regulating several possible factors such as oxidative strain, and renin-angiotensin structure hyperactivity. Nutraceutical derivatives, antioxidants, vitamins, and natural components in food produce effects that are a class of medications that reduce blood pressure 24.
High blood pressure is one of the most relevant independent risk factors of CVDs and the most prevalent all over the world.
Reduction in nitric oxide bioavailability, increase in angiotensin-II and endothelin coupled with endothelial activation initiate the vascular and cardiac dysfunction and hypertension 25.
Dietary folate and plasma ascorbic acid has been found to be inversely associated with blood pressure. Lower risk of elevated blood pressure in the multiple supplement groups suggests that there was a relationship between these nutrients and blood pressure 26.
Nutraceuticals or the supplements of the nutrients of the nutraceuticals reduces the hypertensive condition by lowering blood pressure and increasing antioxidant enzymes.
“Antihypertensive” Foods, Nutrients and Nutraceuticals: The European society of hypertension [ESH] specialists board has published a paper on nutraceuticals and BP control that assorted the natural compounds with clinically measurable consequences on BP in foods, nutrients, and non- nutrient nutraceuticals 27.
“Antihypertensive” Food: It is a food supplement that is used to reduce high blood pressure. Antihypertensive food is a dietary supplement that fulfills the deficiency in the body, which is the biggest cause of hypertension.
Antihypertensive foods are often naturally obtained and used as nutraceuticals without any adulterations. Table 2 shows some food components which is showing antihypertensive properties:
TABLE 2: ANTIHYPERTENSIVE FOOD AND THEIR FUNCTIONS
S. no. | Antihypertensive food | Function / MOA |
1. | Non-roasted green coffee | Coffee or green or lightly roasted coffee is one such phytochemical which has beneficial properties to control CV health and blood pressure27 |
2. | Lycopene | The assumption of BP management where lycopene additive was recommended, tomato intake provided more approving results on cardiovascular risk endpoint than did lycopene supplementations28 |
3. | Green tea | Green tea has potent antioxidant and anti-inflammatory activities, known to conserve and enhance the endothelial function29 |
4. | Garlic | Garlic is effective in decreasing blood pressure in patients with unrestricted hypertension who are already on antihypertensive medications30 |
5. | Beet root juice | The utilization of beetroot juice on a low nitric diet as an origin of inorganic nitrate (NO3) may lower blood pressure28 |
6. | Pomegranate juice | Pomegranate may often find Punica Granatum constituent. Punica granatum L is rich in antioxidant polyphenols. e.g., ellagitannins27 |
7. | Dark chocolate | Cocoa is flavonoids that have been recently investigated. It is an adequate food supplement that plays a possible role in the prevention of CVD31 |
8. | Fermented milk | Epidemiological studies suggest that people who consume more milk have a more desirable blood pressure than those who consume less milk, so dairy supplements are used as a dietary supplement to control high pressure32 |
9. | Nuts | Five large epidemiological studies have thus far; continuous consumption of nuts reduces the risk of CHD. So, it is used as a nutraceutical or as an antihypertensive food, the best known among them being the Adventist health study33 |
10. | Quercetin | Onion is a vegetable that is used in a wide variety of food in the world. It is good in a phenolic compound such as Quercetin which shows an antihypertensive effect through antioxidant properties, and it inhibits the ACE activity and Ca2+ influx34 |
Antihypertensive Nutrients 35: Antihypertensive nutrients are the compounds that are naturally present in our diet with accepted nutritional levels, such as minerals, vitamins, fatty acids, and polysaccharides. Nutrients/minerals are an element that does not maintain blood pressure but prevents the occurrence of arterial hypertension. Table 3 shows the nutrients which are shown antihypertensive properties:
TABLE 3: ANTIHYPERTENSIVE NUTRIENTS/ MINERALS AND THEIR FUNCTIONS
S. no. | Nutrients | Functions / MOA |
1. | Calcium | Calcium is often essential for bone-building or teeth, and it helps to support bone strength and plays a vital role in nerve, muscle, and glandular functions27 |
2. | Iron | Iron helps to assist in energy production, and it also helps to sustain and transmits the oxygen to tissue35 |
3. | Magnesium | Magnesium is necessary to form bone, healthy nerves, and muscle function. It may help to prohibit premenstrual problem27 |
4. | Phosphorous | Phosphorous is also necessary for the building of strong bones and teeth. It assists in the formulation of genetic material, storage, and production of energy35 |
5. | Zinc | Zinc is necessary for the cell replication; normal extension and spread in children, wound relieve production of sperm and testosterone35 |
6. | Flavonoids | The over 4000 flavonoids in fruit, vegetables, red wine, tea, soy, and licorice may decrease the risk factor of high blood pressure, Cerebrovascular accident, and cardiac heart disease30 |
7 | Omega-3 polyunsaturated fatty acids (PUFAs) | Omega-3 polyunsaturated fatty acids indicated mechanisms by which PUFAs may enhance the blood pressure control are numerous: improvement of generation and bioavailability of endothelium-derived moderately factor (NO) through up- Management and activation of endothelial NO synthase, decreased insulin- resistance, and the defeat of the renin-angiotensin-aldosterone system36 |
8. | Vitamins | The vitamins and ascorbate concentration in humans are conversely related to blood pressure. Especially vitamin C also appears to enhance the success of some hypertensive drugs like Amlodipine37 |
9. | Multivitamins | A multivitamin is a nutrient that is most extensively used as a food supplement throughout the world, and there has been a developing interest in the prospective role of multivitamins is decreasing the risk of chronic disease as well as cardiovascular disease, hypertension, cancer, and brain dysfunction38 |
10. | Sterols | The current analysis, which aimed to analyze the consequence of plant stanol esters on arterial stiffness and endothelial function in adults, also established no effect on measured blood pressure and also denoted antihypertensive effects of sterol despite sustained treatment for a year or more 39 |
MATERIAL AND METHOD: A small face-to-face survey has been done on different medical shops/ drug stores in the areas of Dehradun, like near kanwali road, Dharmpur, Premnagar, Ballupur, Rispana, Doon hospital, Jogiwala. We found that some of the drug stores prefer nutraceuticals.
This survey data includes various types of nutraceuticals that are revealed through an offline (face to face) survey from December 15, 2021 to January 10, 2022. In this survey, we have collected data from chemist’s responses.
Survey Report of Nutraceuticals used in Management of Hypertension: Survey is a procedure of convention data from a sample of people, regularly with the purpose of generalizing the effect to a larger population. A survey gives an analytical source of data and awareness for nearly everyone occupied in the particular’s economy, from business and the media to government and academics. There are 4 modes of survey data collection: face-to-face survey, Telephone survey, Self- administered paper and pencil survey, Self- administered computer survey. This face-to-face survey reveals which nutraceuticals are used in the market for the Management of hypertension. Nutraceuticals are often available in the market in the form of tablet; capsule and oral formulations (Syrup).
Most formulations are available in the nutraceuticals market in the form of soft gel capsules. These nutraceuticals also contain some nutrients that can decrease blood pressure, as well as the lack of nutrition in the body, such as due to lack of vitamins, calcium, and magnesium, phosphorous in the body and chronic disease due to lack of nutrients in the body. In this case, nutraceuticals or dietary supplements are also taken. This survey reveals which nutraceuticals are highly demanding in the market. As per the survey, some of the marketed formulations of nutraceuticals are as follows:
Marketed Formulations of Nutraceuticals for Hypertension: As per the survey, the marketed formulation of nutraceuticals is shown in Table 4:
TABLE 4: MARKETED FORMULATIONS OF NUTRACEUTICALS
Types of medicine | Marketed formulation |
Tablet | Super B complex, Alpha-linolenic acid, Allvell- Z grape seed extract, Antioxidant support |
Capsule | Advanced BP support, Natural formula BP Complex, Blood pressure formula, Mactotal, BP rescue, Omega fatty acids grape seed vitamins, Cardio care vegetarian capsule, Cholbiome |
Liquid orals | Vegifruit syrup, Beetroot juice, Beryl tone |
FIG. 2: GRAPH OF MARKETED DEMAND OF NUTRACEUTICALS IN THE FORM OF TABLET
FIG. 3: GRAPH OF MARKETED DEMAND OF NUTRACEUTICALS IN THE FORM OF CAPSULE
FIG. 4: GRAPH OF MARKETED DEMAND FOR NUTRACEUTICALS IN THE FORM OF LIQUID ORALS
These graphs displayed which nutraceutical is preferred for hypertension in the market and which nutraceutical is most demanding in the market. After surveying 33 drugstores, we found that the most demanding nutraceutical is Mac total. This graph shows that most preferred nutraceutical is Mactotal, and the least demanding nutraceuticals are Beryl tone and Allvell-Z grape seed extract.
Marketed Formulation, Ingredients & their Functions: These are some antihypertensive drugs that are used as a marketed formulation of nutraceuticals.
Table 5 includes the composition and the functions of these antihypertensive drugs.
TABLE 5: MARKETED FORMULATIONS OF NUTRACEUTICALS & THEIR FUNCTIONS
S. no. | Antihypertensive nutraceuticals | Composition | Functions | |
1 | Mactotal | Omega 3 fatty acids, green tea
Extract, Ginkgo biloba, Grape Seed extract, Ginseng, Vitamins, Minerals |
Mactotal is used for heart-related a disease. It is a multivitamin supplement used to prevent the deficiency due to poor diet | |
2 | Omega fatty acids, grape seed vitamins | Omega 3 fatty acids, grape seed extract, green tea extract, Ginseng grape seed, Ginkgo biloba extract, multimineral | It reduces body weight and decreases the diastolic blood pressure | |
3 | Advanced BP support | Hawthorn extract, Hibiscus flower, Olive oil, Garlic, Vit.C, Niacin, Vitamin B6, B12 | It helps to keep vessels strong and flexible, and it reduces the risk of heart issue | |
4 | Natural formula BP complex | Hawthorn berry, Forskohlii, Garlic, Hibiscus | It supports healthy blood pr. Levels and helps to feel better. | |
5 | Blood pressure formula | Wolfberry extract, Odorless garlic extract, Sage extract, Olive leaf extract, Rutin | Blood pressure formula helps to support BP levels in the normal range | |
6 | BP rescue | Hawthorn berry, Garlic, Green tea, Coleus Forskohlii, Olive leaf | It is a blood pressure supplement that help lower and maintains blood pressure. | |
7 | Zeovita- 4G | Omega 3 fatty acid, green tea extract, ginkgo biloba, ginseng, grape seed extract, vitamins, minerals | The antioxidants in grape seed extract can potentially protect the blood vessels from becoming damaged, which may prevent high blood pressure | |
8 | Cardiocare capsule | Ginkgo biloba, Lycopene, Nattokinas, Folic acid, Magnesium, Ascorbic acid | It is cardiovascular health begins with keeping the blood pressure and nerve functioning under the control | |
9 | Cholbiome | Lactobacillus, Co- enzyme, L- arginine, Co- enzyme Q10 | It is a CoQ10 in supplement that is purported to improve heart-related conditions like hypertension by neutralizing free radicals, increasing the production of energy in cells, and preventing the formation of blood clot | |
10 | Lutein, glucosinolatic saponins fibers (vegifruit syrup) | Fruit extract, vitamins,
Minerals, Amino acids |
This syrup affects cardiovascular risk factors such as lowering blood pressure | |
11 | Beet juice | Beetroot extracts, vitamins, Multimineral | It is used to help lower level of triglycerides in the blood, and high BP and to improve atheletic performance | |
12 | Beryl tone | Multivitamins, multimineral, lycopene, L- lysine, anti-
Oxidant |
This supplement prevents heart-related disease by reducing oxidative stress, and it also helps to protect cell from damage. | |
13 | Alpha-linolenic acid | Vitamin C& E, Glutathione,
Alpha-linolenic acid |
Alpha-linolenic acid is conception to decrease the risk of heart disease by helping to support normal heart rhythm and pumping | |
14 | Allvell-Z grape seed extract tablet | Grape seed extract, Vitamins,
Folic acid, Manganese, Biotin |
The oxidant in grape seed extract can certainly assure the blood vessels from becoming damaged, which may prevent high blood pressure | |
15 | Antioxidant support | Vitamin C, Green tea extract,
Grape seed extract, Lycopene, Folic acid, Biotin |
It may help to protect the cell from damage caused by free radical and it decreases the risk of high blood pressure | |
CONCLUSION: It is concluded that the above-studied nutraceuticals that is Mactotal, Omega fatty acids grape seed extract, Advanced BP support, Natural formula BP complex, Blood pressure formula, BP rescue, Cholbiome, Zeovita- 4G, Super B complex, Alpha-linolenic acid, Allvell-Z grape seed extract tablet, Antioxidant support, Vegifruit syrup, Beet juice, Beryl tone.
These nutraceuticals and functional foods reduce blood pressure, in which mactotal, this effect is most likely mediated by inhibiting ACE activity, modulating NO production, scavenging free radicals, and improving endothelial function. The most demanding nutraceutical is Mactotal and least demanding nutraceutical is Allvell- Z grape seed extract and Barytone. This surveyed nutraceutical is in huge demand due to their fewer toxic effects and having good self-life as well as long life treatment with dietary foods.
ACKNOWLEDGEMENT: We acknowledge Mr. S. N. Nautiyal (Chairman), Shree Dev Bhoomi Institute of Education, Science and Technology, Dehradun, for the encouragement to do this work.
CONFLICTS OF INTEREST: Authors declare that there is not any conflict of interest.
REFERENCES:
- Ali A, Abu Zar M and Kamal A: American heart association high blood pressure protocol 2017: A literature review. Cureus 2018; 10(8): 1-6.
- Cheung BMY: A 2020 vision of hypertension. Korean Circulation Journal 2020; 50(6): 1-7.
- Writes S and Writer F: Opinion article of common causes of hypertension in adults. Health Science J 2017; 11: 1.
- Fogacci S, Fogacci F and Cicero AFG: Nutraceuticals and hypertensive disorders in pregnancy: The available clinical evidence. Multidisciplinary Digital Publishing Institute Nutrients 2020; 12: 1-10.
- Kruthi BN and Sahana KR: Study on essential hypertension and renal impairment: A descriptive cross- sectional study. International Journal of Research & Review 2019; 6(11): 19-25.
- Hughes AD, Eastwood SV, Tilin T and Chaturvedi N: Antihypertensive medication use and its effets on blood pressure and haemodynamics in a tri- ethics population cohort: Southall and Brent revisited. Frontier in Cardiovascular Medicine 2022; 8: 1-9.
- Verma N, Rastogi S, Chia chin Y, Siddique S, Turana Y, Cheng H, Sogunuru GP, Tay JC, Teo BW, Wang TD, Fai KK and Kario K: Non- pharmacological Management of hypertension. Journal of clinical hypertension 2021; 1-9.
- Sabaka P, Dukat A, Gajdosik J, Bendzala M, Caprnda M and Simko F: The effect of body weight loss and gain on arterial hypertension control: an observational prospective study. European Journal of Medical Research 2017; 22-43.
- Grillo A, Salvi L, Coruzzi P, Salvi P and Parati G: Sodium intake and hypertension. Multidisciplinary digital publishing Institute, Nutrients 2019; 11; 1-16.
- Pedralli ML, Eduedo B and Cunha PG: Hypertension: Protective effect of physical exercise on cognition function, arterial function and brain health. Association for research into Arterial Structure and Physiology 2019: 1-6.
- Asamoah CN and Setorglo JJB: Nutritional counceling for hypertension patients. Hindwani Journal of Biomedical Education 2017; 1-9.
- Hussain B, Sajid MA, Nabeel M, Saeed A and Shah AA: Study of assessment of knowledge of patients and health care professionals about the use of nutraceuticals. World journal of pharmaceutical research 2020; 9(6); 49-119.
- Nawsheen Bee T and Hananeh Abdolrahman R: Nutraceuticals: Nutritionally functional foods- an overview. Biomedical Journal of Science & Technical Research 2019; 4(15): 11480-11482.
- Chaudhari SP, Powar PV and Pratapwar MN: Nutraceuticals: a review. World Journal of Pharmacy and Pharmaceutical Science 2017; 6(8): 681-739.
- Salem AA and Shahawy NA: Hippocrates’s advice and nutritional secrets. Open Journal of Nutrition and Food Science 2020; 2(1): 52-54.
- Keerthana M, Jemimah G, Reddy TS, Bonagiri Y and Gupta AV: Nutraceuticals for prevention for prevention of various disease conditions. Indo American Journal of Pharmaceutical Sciences 2019; 6(11): 14421-14427.
- Dutta S, Ali KM, Dash SK and Biplab G: Role of nutraceuticals on health promotion and disease prevention: a review. Journal of Drug Delivery and Therapeutics 2018; 8(4): 42-47.
- Ahad T, Nissar J and Rather AH: Nutraceuticals- health benefits: a review. International Journal of Engineering Technology Science & Research 2017; 12(4): 262-267.
- Shelke S, Salunkhe A and Galave V: Health benefits of nutraceuticals: a review. International J of Research in Engineering Science & Management 2020; 5(3): 524-527.
- Kaur S, Kumar M, Pandit K, Kumar A and Kaur S: Potential health benefits of nutraceuticals for human health. Environmental Contaminants and Natural Products 2019; 9; 192-208.
- Nwosu OK and Ubaoji KI: Nutraceuticals: history, classification& marketed demand. Functional foods and Nutraceuticals 2020; 2: 13-22.
- Chanda S, Tiwari RK, Kumar A and Singh S: Nutraceuticals inspiring the current therapy for life style disease. Hindwani Advances in Pharmacological Science 2019; 1-5.
- Ruby S, Prakash S, Kumar PV and Kumar PT: A comprehensive review on nutraceuticals. International Journal of Pharmaceutical Science Review and Research 2021; 2(68): 136-148.
- Houston MC: Treatment of hypertension with nutrition and nutraceutical supplements: part1. Alternative and Complementary Therapies 2018; 6(24): 260-275.
- Yan X, Zhang QY, Zhang YL, Han X, Guo SB and Li HH: Gallic acid attenuates angiotensin II- induced hypertension and vascular dysfunction by inhibiting the degradation of endothelial nitric oxide synthase. Frontier in Pharmacology 2020; 11: 1-10
- Srivastava R, Sangha JK and Kochhar A: Impact of ascorbic acid and nutrition counseling on lipid profile and blood pressure of hypertension and hyperlipidemic participants. International Journal of Multidisciplinary Education Research 2019; 8(4): 8-16.
- Borghi C, Cicero FG:Nutraceuticals and blood pressure; scientific newsletter updates on hypertension management. European society hypertension2021; 77(24): 1-3.
- Cicero AFG and Colletti A: Nutraceuticals and blood pressure control: results from clinical trials and Meta analysis. High Blood Pressure & Cardiovascular Prevention 2015 (online): 1-10.
- Li D, Wang R, Huang J, Cai Q, Yang CS, Wan X and Xie Z: Effect of mechanisms of tea regulating blood pressure: evidences and promises. Multidisciplinary digital publishing institute Nutrients 2019; 11: 1-20.
- Houston MC: The role of nutrition and nutraceutical supplements in the prevention and treatment. Future medicine part of future science group clinical Practice 2013: 209-229.
- Corina Z and Otelea MR: Dark chocholate: to eat or not to eat? a review. Journal of AOAC international 2019; 102: 1-9.
- Lu TM, Chiu HF, Lu YY, Han YC, Shen YC, Venkatakrishnan K and Wang CK: Efficacy of fermented milk on blood pressure in prehypertensive adults: a randomized, placebo- controlled, clinical trial. Journal of Food Biochemistry 2017; 1-7.
- Estruch R, Ros E, Salvado JS, Covas MI, Corella, Borau FA, Gracia EG, Guteierrez VR, Fiol M, Laetra J, Raventos RL, Majem LS, Pinto X, Basora J, Munoz MA, Sorli JV, Alfredo M, Fito M, Gea A and Gonzalez MAM: Primary prevention of cardiovascular disease with a mediterrranean diet supplemented with extra- virgin olive oil or nuts. New England Journal of Medicine 2018; 378(25); 1-14.
- Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schafer B, Hirsch- Ernst KI and Lampen A: Safety aspects of the use of Quercetin as a dietary supplement. Molecular Nutrition & Food Research 2017; 62(1): 1-15.
- Ghani U, Naeem M, Rafeeq H, Imtiaz U, Amjad A, Ullah S, Rehman A and Qasim F: A novel approach towards nutraceuticals and biomedical applications. Scholars International Journal of Biochemistry 2019; 10(2): 245-252.
- Cicero AFG, Grassi D, Tocci G, Galletti F, Borghi C and Ferri C: Nutrients and nutraceuticals for the Management of high normal blood pressure: an evidence- based consensus document. High blood pressure & cardio vascular prevention 2019 (online): 1-17.
- Singh V and Sourav U: Efficacy and tolerability of vitamin C as an added-on therapy to standard antihypertensive regimen. International Journal of Basic & Clinical Pharmacology 2021; 10(1): 90-94.
- Bronzato S and Durante A: Dietary supplements and cardiovascular disease. Int J of Preve medi 2018; 9(1): 1-6.
- Sosnowska B, Penson P and Banach M: The role of nutraceuticals in the prevention of cardiovascular disease. An International open access journal covering cardiovascular medicine and survey2017; 7: S21-S31.
How to cite this article:
Saini R, Nautiyal A and Patil S: Emerging role of nutraceuticals in the management of hypertension: a systematic review. Int J Pharm Sci & Res 2023; 14(1): 62-70. doi: 10.13040/IJPSR.0975-8232.14(1).62-70.
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IJPSR
Rita Saini *, Anupriya Nautiyal and Shivanand Patil
Department of Pharmacy, Shree Dev Bhoomi Institute of Education, Science and Technology, Poundha, Dehradun, Uttarakhand, India.
reetpharma@gmail.com
05 April 2022
04 June 2022
17 June 2022
10.13040/IJPSR.0975-8232.14(1).62-70
01 January 2023