ENHANCED ANTIMICROBIAL ACTIVITY OF PROBIOTICS THROUGH SELENIUM NANOPARTICLES ENRICHMENT AGAINST GASTROINTESTINAL PATHOGENS

The decrease in susceptibility towards commonly administered antibacterial agents is due to excessive use of antibiotics every now and then, due to which the resistance toward these antibiotics is developed in pathogens. To overcome the problem of resistance in pathogenic microbes, the study of incorporation of Selenium metal to probioticts supplement was carried out. Antimicrobial activity of individual broth obtained from five different lactobacillus spp. viz. Lactobacillus helveticas, Lactobacillus fermentum, Lactobacillus acidophilus, Lactobacillus gasseri strains with varying concentration of Selenium (20mg/mL, 40mg/mL, 60mg/mL and 80mg/mL) were studied against pathogens like Staphyllococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi and Candida albicans. The results showed that the antimicrobial property of the probiotic broth was significantly increased and showed good bacteriostatic activity against on Staphyllococcus aureus, Escherichia coli and Candida albicans. The report and such kind of further studies may pave the way for further investigations on the use of pure metals as effective antibacterial agents to overcome the problem of resistance in pathogens.