ENHANCEMENT OF BIOAVAILABILITY OF NORFLOXACIN MUCOADHESIVE SUSPENSION BY USING DIFFERENT GRADES OF CARBOPOL

Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone.   Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability and to increase the residence time of drug by bringing the drug in the vicinity of absorption window by formulating it in mucoadhesive drug delivery system. An attempt has been made to increase the bioavailability of Norfloxacin by formulating mucoadhesive suspension in different Polymers. Increase in time, speed of homogenization decreases the particle size and increases the zeta potential. Batches formulated with soyalecithin, antinucleating agents, showed decreased particle size. The comparative studies of dissolution studies showed, 99.55% of processed suspension released in 10Min. as compared to 101.63% released in 40Min. for marketed suspension respectively. The reason for increased percent release of drug in short time (10Min.), for processed suspension is, more time, speed and cycles of stirrer. These variables lead to increase in surface area of particle. It was found that the various parameters for bioavailability were enhanced by Carbopol 971P.