ENHANCING THE PROPRANOLOL HCL BIOAVAILABILITY IN RATS WITH NARINGIN: A ROLE IN PERMEABILITY GLYCOPROTEIN (P-GP) INHIBITION
AbstractDrug transporters altered functions may affect pharmacokinetics, which in turn may affect a drug in blood levels. The maintenance of an appropriate serum concentration of a drug is important to ensure therapeutic efficacy. Bio enhancers, or naturally generated drug absorption enhancers, increase the quantity of unchanged medication in the systemic blood circulation by controlling pre-systemic metabolism and/or membrane permeability. In this study, we have focused on the influence of functional alterations in the intestinal P-glycoprotein (P-gp) on the PK (Pharmacokinetic) of drug by the oral route after pre-treatment with Naringin and verapamil as standard. The interaction between drug and Naringin has been studied using in-vitro noneverted sac study, in-situ Single-Pass Intestinal Perfusion (SPIP) study, and in-vivo oral bioavailability study in rats using Bioanalytical method in RP-HPLC. The bioavailability of drug is improved with Naringin, and this combination is better than verapamil combination of drug, and further studies are needed to confirm the results in patients.
Article Information
30
1033-1038
573 KB
2
English
IJPSR
Ramgopal Goud Bathini * and Swaroopa Rani Vanapatla
Department of Pharmacognosy and Phytochemistry, Kakatiya University, Warangal, Telangana, India.
ramgopal22399@gmail.com
07 October 2025
26 October 2025
12 November 2025
10.13040/IJPSR.0975-8232.17(3).1033-38
01 March 2026
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