ESTIMATION OF MANIDIPINE DIHYDROCHLORIDE BY A NEW RP-HPLC METHOD
AbstractA rapid reverse phase high performance liquid chromatographic method was developed for the estimation of Manidipine dihydrochloride in its pure form as well as in tablet dosage forms. Chromatography was carried out on an phenomenex C18 column (250´4.6mm, 5 µm), using a mixture of acetonitrile and water (80: 20 v/v) with pH adjusted to 3.5 with ortho phosphoric acid (0.1 % v/v) as the mobile phase at a flow rate of 1.3 mL/min The detection wavelength is 230 nm. The retention time of the drug was 3.54 min. The method produced linear responses within concentration range of 25 to 125 µg/mL of Manidipine dihydrochloride. The method was found to be reproducible for analysis of the drug in tablet dosage forms.
Article Information
64
3375-3378
447KB
1315
English
IJPSR
Raja Sundararajan*, Christopher Vasanth Kumar and Jayaveera
GITAM Institute of Pharmacy, GITAM University, Visakhapatnam- 530 045, Andhra Pradesh, India
sraja61@gmail.com
24 May, 2012;
14 July, 2012
28 August, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3375-78
01 September, 2012
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