EVALUATION OF α – AMYLASE INHIBITORY ACTIVITY OF SOME CLINICALLY USED DRUGS
AbstractFinding out the alternative uses of the clinically proven and time tested drugs can be one of the best options for drug discovery research. In view of this the present study was carried out to evaluate α-amylase inhibitory activity of the some of the commonly used drugs. The drugs were procured as gift samples from pharmaceutical companies and were evaluated for in-vitro α-amylase inhibitory activity using a colorimetric assay. The results revealed that Buspirone, Amlodipine, Diltiazem, Verapamil, Chlorpheniramine maleate and Cetirizine had prominent α – amylase inhibitory potential in comparison to Acarbose. The drugs exhibiting prominent in-vitro α- amylase inhibitory activities are to be further evaluated in the in-vivo models so that can be used as add – on therapy in diabetes patients.
Article Information
29
1843-1846
555KB
1467
English
IJPSR
Harish C. Rodda*, T. Sandhya and P. Swetha
Department of Pharmacognosy, Phytochemistry Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda, Warangal – 506001, India
hcrodda@hotmail.com
02 December, 2013
14 January, 2014
09 March, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(5).1843-46
01, May 2014
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