EVALUATION OF ACUTE ORAL TOXICITY, ANTINOCEPTIVE AND WOUND-HEALING ACTIVITIES OF ETHANOLIC AND AQUEOUS ROOT EXTRACTS OF COMBRETUM GLUTINOSUM PERR. EX DC

In Ivory Coast, the use of traditional medicinal plants is common because it’s low cost and also the scarcity and expensive nature of hospitals for so-called modern drugs. In addition, different types of herbal and others are used to heal wounds. Among these medicinal plants, the root of Combretum glutinosum is strongly recommended by traditional activists even though their in-vivo wound healing activity is not reported. Phytochemical screening of Combretum glutinosum revealed the presence of sterols and polyterpenes, polyphenols, flavonoids, catechic tannins, gallic tannins, alkaloids, saponosides, anthraquinones terpenoids, and anthocyanins. Some researchers claim that these bioactive compounds obtained from the phytochemical analysis may be responsible for pharmaceutical activity. All plant extracts studied had LD₅₀ values greater than 3000 mg/kg body weight and were therefore considered harmless. The study showed that the aqueous and ethanolic root extracts of Combretum glutinosum (AECG and EECG) have analgesic effects. Hence, they have the potential to offer safe pain-relieving compounds. The aqueous and ethanolic root extracts of Combretum glutinosumwith Cocoa butter (AECG_25% and EECG_25%) have been shown to support traditional wound healing claims, as evidenced by an increase in the rate of wound contraction and tensile strength, thus translating to a decrease in wound healing.