EVALUATION OF ANTIDEPRESANT ACTIVITY OF SPINACIA OLERACEAE BY USING ALBINO RATS
AbstractHerbal and natural products of folk medicine have been used for centuries in every culture throughout the world. Scientists and medical professionals have shown increased interest in this field as they recognize the true health benefits of these remedies. Spinach is a leafy green vegetable that came originally from south-western Asia and is now grown in most parts of the world. Scientifically it is known as Spincia oleracea Linn. (Family-Chenopodiaceae). It is a good source of the bioflavonoid quercetin with many other flavonoids which exhibits anti-oxidant, anti-proliferative, anti-inflammatory, antihistaminic, in addition to its many other benefits. Treatment with Spinacia oleraceae (200mg/kg body wt) decreases the immobility time against forced swim test and tail suspension test. Fluoxetine (30mg/kg, i.p) was selected as reference standard and it showed significant antidepressant activity in rodents. Results suggest that Spinacia oleraceae exerts anti-depressant activity as shown by its effects on different experimentally induced different models
Article Information
31
4692-4696
446KB
1179
English
IJPSR
Rajya Laxmi Gudepu*, S.V. Mahalakshmi Rampalli and J. Yasodha Krishna
Department of Pharmacology, Sri Sarada College of Pharmacy, Bhongir, Nalgonda- 508116, Andhra Pradesh, India
rajyalaxmigudepu@gmail.com
30 July, 2013
30 August, 2013
28 November, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(12).4692-96
01 December 2013
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