EVALUATION OF ANXIOLYTIC ACTIVITY OF HYDROALCOHOLIC ACTIVITY OF TEPHROSIA PURPURIA (L) PERS ON SWISS ALBINO MICE
AbstractThe present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 mg/kg and 400 mg/kg, was able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze and elevated zero-maze, as well as decrease the visits by mice in the Y-maze, also significantly increase nose poking, line crossing and rearing in hole-board. This effect was comparable to that of the diazepam (2.0 mg/kg i.p.). These results indicate that hydroalcoholic extract Tephrosia purpuria (L) Pers is an effective anxiolytic agent.
Article Information
26
1262-1269
576
1460
English
Ijpsr
A. Sathish Kumar*, P. Amudha and C. Satheesh Kannan
Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Chennai, Tamil Nadu, India
12 February, 2011
11 March, 2011
12 April, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(5).1262-69
01 May, 2011
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