EVALUATION OF AQUEOUS LEAF EXTRACT OF SAPINDUS SAPONARIA ON CARBOHYDRATE METABOLIZING ENZYMES IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Diabetes mellitus (DM), a longtime metabolic illness characterized with the high concentration of glucose residue in the blood, is one of the key global health issues because of the prevalence and chronic outcomes. The traditional plant remedies in tackling the condition have attracted attention as an alternative to the conventional therapies, which are usually associated with undesirable side effects. The current study grasps the growing momentum in the scientific testability of the medicinal plants considering their portentious biochemical depth and the advisability of regulating key processes of metabolism. To elaborate the peculiar enzymatic activities inhibited by Sapindus saponaria leaf extract and to comprehend about the antidiabetic activities of the extracts, the study investigated the effects of the extract on carbohydrates metabolism in this research. The study demonstrates that the extract has a substantial effect on carbohydrate metabolism-related enzymes, and can propose its potential use as a diabetes treatment. The capacity of an aqueous extract of Sapindus saponaria leaves to affect the antidiabetic properties was explained by measuring the influence of these extracts on the enzymes responsible of breaking down the carbohydrates of the model being streptozotocin-induced diabetic rats. Further research of the topic should be aimed at isolating and characterizing the bioactive molecules through isolation and characterization and elucidation into the mechanism of action by which they act. Thereafter, clinical testing done to ascertain the safety and the efficacy of the extract in treating diabetes mellitus in human beings.