EVALUATION OF CO-ADMINISTRATION OF MURRYA KOENIGII LEAVES AND MOMORDICA CHARANTIA FRUITS ON ANTIULCER ACTIVITY IN EXPERIMENTALLY INDUCED ULCERS IN RATS

In this study, the preventive and protective potentials of Murray koenigii (MK) leaves and Momordica charantia (MC) fruit extracts against experimentally induced peptic ulcers in Wistar rats were evaluated. Rats were divided into six experimental groups – normal (saline), control (ulcers), pretreatment with MC extract (fresh fruit juice, 500ml/kg), MK extract (400mg/kg)or both, and pretreatment with standard drug ranitidine (RTD). Parameters assessed in the study were -ulcer score, ulcer index, free acidity, total acidity, percentage of ulcer inhibition, pH of gastric juice, gastric volume, C-reactive protein, macroscopic evaluation of the stomach, and histopathological studies. The results of the pharmacological studies on the co-administration of MK extract and MC juice showed a significant decrease in ulcer score, ulcer index, gastric volume, free acidity, total acidity, and CRP value when compared to positive control. The pH and percentage of ulcer protection were significantly increased in the co-administration extracts treatment group comparably with the standard ranitidine group. Hence, the study revealed that pre-treatment with the combined administration of Murraya koenigii leaves and Momordica charantia fruit extracts improves the amelioration of gastric ulcers & proved to be cytoprotective and inhibits the occurrence of peptic ulcers in rats.