EVALUATION OF CORRELATION BETWEEN GLYCATED HEMOGLOBIN AND HEMATOLOGICAL INDICES IN TYPE 2 DIABETES MELLITUS PATIENTSAbstract
Diabetes Mellitus increases the risk of both microvascular and macrovascular complications, out of which CVD affects approximately 32.2% of people with Type 2 Diabetes Mellitus globally. It is predicted that for every 1% increase in HbA1c is associated with a 30% increase in all-cause mortality and a 40% increase in CVD mortality in T2DM patients. This study aims to evaluate the correlation of HbA1c% with various hematological indices and to elucidate the possible changes in some hematological and lipid parameters in people with poor glucoregulation. A total of 76 patients of both gender with type 2 DM were included in the study after fulfilling the exclusion and inclusion criteria. Data from complete blood picture reports of the subjects were collected and documented. The collected data includes the values of HbA1c, some elements of complete blood picture, and lipid profile. The subjects were divided into two categories with HbA1c% ≤ 7 and HbA1c% > 7. All blood parameters under study except lymphocytes showed a significant mean increase in subjects with HbA1c% > 7. HbA1c showed a statistically significant positive correlation with MCHC (r=0.310), RDW(r=0.584), WBC(r=0.453), MPV(r=0.709), TC(r=0.471), TG(r=0.426) and VLDL(r=0.437) at p-value < 0.05. Neutrophils and MCH showed no significant positive correlation, and lymphocytes count was negatively correlated with HbA1c. Our study concluded that HbA1c% was positively correlated with MCHC, RDW, MPV, WBC, TC, TG, and VLDL. Hyperlipidemia was also found to be persistent among patients with poor glycemic status, which is associated with a higher risk of cardiovascular-related mortality and morbidity.
Kumaraswamy Barla * and S. V. Kavya
Department of Pharmacology and Pharmacy Practice, Sir C. R. Reddy College of Pharmaceutical Sciences, Eluru, Andhra Pradesh, India.
15 October 2020
10 February 2021
24 May 2021
01 October 2021