EVALUATION OF ENDOCAN AND ENDOGLIN AS PREDICTIVE MARKERS OF ENDOTHELIAL DYSFUNCTION IN WISTAR ALBINO RATS TREATED WITH A SINGLE DOSE OF STZ AND HFD

A major susceptibility indicator for type 2 diabetes and cardiovascular diseases is obesity-related insulin resistance. Vascular endothelial cells strongly express the coreceptors for members of the transforming growth factor (TGF) superfamily, endocan and endoglin. Examining endocan and endoglin as potential indicators of cardiovascular complications in HFD rats with or without type 2 diabetes mellitus is the goal. The following four groups; normal diet-HFD, normal diet-STZ, and HFD-STZ were each comprised of eight wistar rats. Both types of type 2 DM groups had significantly higher levels of plasma glucose, insulin, glycosylated haemoglobin (HbA1c), and homeostatic model assessment (HOMA-IR) when compared to the control group (P <0.001). Comparing the HFD and HFDSTZ groups to the STZ and control Normal Diet groups, respectively, the serum lipid patterns in the HFD and HFD-STZ groups were drastically different levels were seen in comparison to the control group in all groups, but the HFD STZ- group had higher percentage change values. Both the HFD-STZ and the normal diet STZ groups had significantly higher levels of soluble endoglin in their sera (P< 0.001), and these elevations were similar to those of VCAM. In the Normal Diet and HFDSTZ groups, soluble Endocan and endoglin significantly correlated with plasma glucose, insulin, and HOMA-IR as well as with total cholesterol in the groups HFD and HFD-STZ. Consequently, soluble endocan, endoglin may suggest they are useful.