EVALUATION OF MELATONIN AND COENZYME Q10 FOR GASTROPROTECTIVE EFFECT IN ASPIRIN AND IBUPROFEN INDUCED GASTRIC ULCERS IN RATS

The present study was carried out to evaluate the gastroprotective effect of melatonin, coenzyme Q10 (CoQ10) and its combinations with rabeprazole in aspirin (400 mg/kg) and ibuprofen (300 mg/kg) induced gastric ulcers in albino Wistar rats. In aspirin-induced gastric ulcer model, the treatment of melatonin (20 mg/kg), CoQ10 (100 mg/kg) and rabeprazole (20 mg/kg) for 10 days significantly reduced the ulcer index with the values of 1.333 ± 0.30, 1.250 ± 0.2 and 0.916 ± 0.18 respectively whereas the ulcer index of combination treatment of melatonin with rabeprazole and CoQ10 with rabeprazole for 10 days was found to 0.416 ± 0.12 and 0.250 ± 0.11 respectively compared with control wherein the ulcer index was 2.88 ± 0.16. In ibuprofen induced gastric ulcer model, the treatment of melatonin (20 mg/kg), CoQ10 (100 mg/kg) and rabeprazole (20 mg/kg) for 10 days significantly reduced the ulcer index with the values of 1.500 ± 0.21, 1.417 ± 0.15 and 0.833 ± 0.27 respectively whereas the ulcer index of combination treatment of melatonin with rabeprazole and CoQ10 with rabeprazole for 10 days was found to 0.583 ± 0.20 and 0.333 ± 0.10 respectively compared with control wherein the ulcer index was 2.500 ± 0.34. The combination treatment of rabeprazole with melatonin and rabeprazole with CoQ10 has shown better gastroprotective effect compared to rabeprazole alone. Treatment of CoQ10 with rabeprazole showed more gastroprotection than the treatment of melatonin with rabeprazole in both aspirin and ibuprofen induced gastric ulcers.