EVALUATION OF THE ANTIDEPRESSANT ACTIVITY OF TRIBULUS TERRISTRIS IN DIABETIC DEPRESSION IN RAT MODEL

Tribulus terristris is a well known medicinal plant as anti-inflammatory, antimicrobial and nephroprotective etc. It is a very good drug for urinogenital problems, hepatic problems, oxidative stress etc. The aim of the study is to compare the depression induced by PCPA and STZ treated diabetic depression in mice and which  could be restored by the ethanolic exact of fruits of Tribulus terristris in 21 days. Method: Depression was created in animals by PCPA (100 mg/k.b.w i.p. for 4 days) and STZ (25 mg/k.b.w i.p for 4 days) induced diabetic depression. Then that depression was restored by ethanolic extract of fruits of Tribulus terristris in a dose of 400 mg/k. b.w/day for 21 days. Fluoxietin kept as standard (5 mg/k.b.w) and continued for 21 days. Depression accessed by forced swimming test and measured the selected antioxidants level in brain homogenate and blood serum. Result: Tribulus terristris (TT) showed significant decrease in immobility in forced swim test and restored the antioxidant levels in animals as fluoxietin does, at the dose of 400 mg/k.b.w. Conclusion: Hence the result proposed that Tribulus terristris has antidepressant and antioxidant properties in chronic treatment of 400mg /k.b.w.