EVALUATION OF THE ANTIMICROBIAL, ANALGESIC AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF THE LEAVES OF AVERRHOA CARAMBOLA

Aim: Evaluation of the antimicrobial, analgesic and antioxidant activity of ethanolic extract of the leaves of Averrhoa Carambola. Materials and methods: To test the antimicrobial activity the organisms used were S. aureus, Klebsiella sp, E. coli and P. aeruginosa, C. albicans. Zone of inhibitions produced by sensitive organisms were demarcated by a circular area of clearing around plant extract impregnated discs and were compared with zone of inhibitions of positive controls. Analgesic activity was tested by two methods: acetic acid induced writhing test and Eddy’s hot plate mediated pain reaction. The animals were divided into 5 groups: Group I (Normal control), Group II (Standard drug), Group III, IV, V (Etahnolic extract of A.carrambola in the doses of 100, 200 and 400mg/kg respectively). To test the antioxidant activity, the mice were divided into 6 groups containing. Paracetamol in the dose of 250mg/kg p.o was administered to all the groups except the first group, which was taken as the normal control, for 10 days to induce oxidative stress. Silymarin in the dose of 25mg/kg p.o was given to the third group as a standard antioxidant. Group IV, V and VI received extract in the dose of 200mg/kg, 400mg/kg and 800mg/kg respectively. Result: Mean±SEM values were calculated for each group. The data were analyzed using ANOVA and post analysis was done by Dunnett’s test. Results were found to be significant (p<.05). Conclusion: The results of the present study revealed the antimicrobial, analgesic and antioxidant activity of the leaf ethanolic extract of A.carrambola