EVIDENCE BASED ANTI-DEMENTING ACTIVITY OF SARASWATA GHRITA “A NOOTROPIC COMPOUND FROM AYURVEDAAbstract
Life expectancy is increasing as a result of advancement in medical science and the availability of better healthcare services. As the risk of dementia increases with increasing age, the number of persons with dementia in the general population is also rising. Alzheimer’s disease is the most common form of dementia, accounting for approximately 70% of the dementia cases. So far, efforts to find a cure for Dementia have been disappointing, and the drugs currently available to treat the disease address only its symptoms and with limited effectiveness. Apart from genetic susceptibility, chronic exposure to other toxins, free -radical damage, Diabetes, high blood pressure, and high cholesterol, high homocysteine level are the major risk factors for Alzheimer’s and stroke-related dementia. Reducing oxidative stress by anti-oxidants, protecting brain inflammatory lesions using anti-inflammatory drugs and facilitation of brain cholinergic neurotransmission with anti-cholinesterase are some positive approaches to management for dementia especially in Alzheimer’s disease. Saraswata ghrita, a polyherbal medhya compound drug used in traditional medicine for cognition and memory related problems is blended with the drugs, which exert a variety of pharmacological actions including anti-inflammatory, anti-amyloidogenic, anti-cholinesterase, hypolipidemic, and antioxidant properties. This paper encompasses the brief descriptive information of different scientific studies on various ingredients of Saraswata ghrita.
Obed Ahmed Ansari, J.S. Tripathi and Sayema Ansari
Division of Manas Chikitsa (Psychosomatic Medicine and Neuropsychiatry), Department of Kayachikitsa, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
11 June, 2013
30 July, 2013
26 October, 2013
01 November, 2013