EXEMPLIFYING THE ANTIDYSLIPIDAEMIC POTENCY OF PTEROCARPUS MARSUPIUM EXTRACT IN MITIGATING HIGH-FAT DIET-INDUCED DYSLIPIDAEMIA IN RODENT MODEL
AbstractWe evaluated the antidyslipidemic activity of extract of Pterocarpus marsupium (PM: Vijayasar) in adult Charles Foster rats of both sexes and compared this activity with that that of Atorvastatin (Atorva). 4 groups were made [Gp 1- Control group (no drug), only high fat diet (HFD); Gp 2- HFD +PM (to evaluate the role of PM in the prevention of dyslipidemia); Gps 3 & 4- only HFD]. This was the phase of disease production [for 7 weeks] and preventive role of PM was also evaluated concurrently. Then, therapy phase started for next 90 days [Gp 1- Control group (no drug). Only HFD; Gp 3- HFD+ Atorva; Gp 4- HFD+ PM]. TC (total cholesterol), TG (triglycerides), LDL (low density lipoproteins) and HDL (high density lipoproteins) levels were tested. During both the phases (prevention and therapy), PM brought significant improvements in all these parameters. Therefore, Pterocarpus marsupium, as an economical herbal therapeutic approach; presents a cost-effective, secure and efficacious means to address significant public health issues; such as dyslipidaemia, coronary artery disease and Atherosclerosis.
Article Information
24
2378-2386
1019 KB
123
English
IJPSR
Anubhuti Shukla, Rakesh Verma *, Shraddha Mishra and Amit Singh
Department of Pharmacology, IMS, BHU, Varanasi, Uttar Pradesh, India.
rakeshverma.kgmu@gmail.com
05 March 2024
03 April 2024
17 May 2024
10.13040/IJPSR.0975-8232.15(8).2378-86
01 August 2024
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