EXPLORING THE EFFECTIVENESS OF PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS IN MIGRAINE MANAGEMENT: A COHORT PERSPECTIVE

Background: Migraine is a common neurological disorder that presents significant challenges in treatment. Effective management is crucial due to debilitating nature of the condition. Aim: This meta-analysis aims to evaluate efficacy of both pharmacological and non-pharmacological interventions in managing migraine symptoms. Methods: The analysis included 13 studies focusing on various interventions for migraine management. Both pharmacological treatments and non-pharmacological approaches were assessed for their effectiveness. The efficacy of these interventions was measured using statistical methods, including weight difference, standardized mean difference (SMD), and mean difference (MD). Funnel plot analyses were conducted to check for publication bias. Results: Pharmacological interventions showed substantial efficacy compared to placebo, with a significant weight difference of 100.0%, a Z-value of 17.58, and a P-value of less than 0.00001. Non-pharmacological interventions also demonstrated significant effectiveness, with a Z-value of 11.62 and a P-value of less than 0.00001. However, there was considerable heterogeneity among the studies, as indicated by the following statistics: for MD, Chi² = 24.65 with 13 degrees of freedom and a P-value of 0.03; for SMD, Chi² = 22.86 with 13 degrees of freedom and a P-value of 0.04. Funnel plot analyses revealed no evidence of publication bias. Conclusion: The findings underscore the potential benefits of both interventions in managing migraines. However, the considerable heterogeneity among the studies suggests that results should be interpreted with caution. Personalized treatment approaches are recommended to optimize patient outcomes. Further research is needed to refine treatment protocols and better understand the underlying mechanisms to improve patient care