FABRICATION AND CHARACTERIZATION OF DRUG-LOADED BIONANOFIBERS AS A PLATFORM FOR DRUG DELIVERY
AbstractThe Bionanofibers drug delivery systems can reduce toxicity, improve therapeutic efficacy and increase patient compliance by delivering drugs at a controlled rate to the site of action. The major aim in designing nanostructures as delivery systems is to deliver pharmacologically active molecules with accurate doses at targeted sites. The present research work developed Bionanofibers as a carrier for drug delivery. Because of the very small nanoscale diameter and high surface area, significantly higher drug content can be loaded in a very small volume. Bionanofibers were manufactured from Macitentan drug using PVP and Soybean PC by electrospinning. The obtained bionanofibers were characterized based on morphology, entrapment efficiency, and drug release behavior. FE-SEM images showed that the length of obtained bionanofibers is about 580nm to 1250nm in diameter. FTIR analysis shows no significant interaction between the drug and the polymer. The in-vitro release study demonstrated that there is a controlled release pattern of drugs from bionanofibers.
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