FABRICATION AND EVALUATION OF ELASTOSOMES OF BOSWELLIA SERRATA FOR TRANSDERMAL DRUG DELIVERY
AbstractThe extracts of Boswellia serrata possess notable medicinal uses. Boswellia serrata is a highly lipophilic drug. It undergoes extensive hepatic first-pass metabolism. The t1/2 is approximately 6 h. There are reported side effects with the administration of Boswellia serrata. This research work aims to fabricate Elastosomes which get hold of many desired features for transdermal drug delivery. The Elastosomes are prepared using thin-film hydration technique using edge activators like Span 80, Tween 80, and Brij 30. The prepared elastosomes are evaluated for entrapment efficiency percentage (EE %), particle size (PS), polydispersity index (PDI), zeta potential (ZP), deformability index (DI), drug release study, and permeation study. EF-10 was regarded as the optimized formulation with all the desired characteristics. The optimized formulation (EF-10) resulted in better prolong drug release and sustained therapeutic action as compared to the marketed product.
Article Information
32
6207-6212
682
845
English
IJPSR
N. P. Griddaluru * and A. Uppala
Department of Industrial Pharmacy, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.
priyanka.sivakumar19@gmail.com
04 December 2019
04 April 2020
20 November 2020
10.13040/IJPSR.0975-8232.11(12).6207-12
01 December 2020
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