FAST DISSOLVING CELECOXIB TABLETS CONTAINING SOLID DISPERSION OF CELECOXIBAbstract
Celecoxib is a selective cox-2 inhibitor is indicated to the treatment of Osteoarthritis, Rheumatoid arthritis, acute painful primary Dysmenorrhoea. It is also superior to other NSAID’s, due to lower incidences of symptomatic gastrointestinal ulcer complications than other NSAID’s. Celecoxib is practically insoluble in water. The present investigation deals with enhancement of dissolution rate of Celecoxib using Mannitol as carrier with different techniques like physical mixtures, kneading method and solvent evaporation method. The dispersions were evaluated for drug content uniformity, dissolution rate study, T50, DE20, ANOVA. The FTIR & DSC were used to characterize solid state of solid dispersions. A marked increased in the dissolution rate was observed with all solid dispersions, among that Celecoxib : Mannitol (1:4) KM. Showed maximum drug release which was selected for formulation of tablets and evaluated for drug release characteristics. The promising formulation (F2) was then compared with existing marketed product, the release profiles was studied in water containing 2 % SLS. The release study showed that these are fast release formulations of Celecoxib. So it is clearly evident that F2 and marketed product are greater than the pure drug .F2 subjected to stability studies the formulation was found to be stable for 4 weeks at 400c, with insignificant change in the hardness, disintegration time and in-vitro drug release pattern.
S. Muralidhar*, G. Devala Rao, V. Rajesh Babu, T. Karunakar Reddy and Syeda Rana Nikhat
Dr. HLT College of Pharmacy, Channapatna, Bangalore (Karnataka), India
24 May, 2010
14 July, 2010
29 August, 2010
15 September, 2010