FLOATING DRUG DELIVERY SYSTEM: A REVIEW
AbstractThe purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the types of floating drug delivery systems, principal and mechanism of floatation to achieve gastric retention. Drug delivery systems are those that float immediately upon contact with gastric fluids present promising approaches for increasing the bioavailability of drugs with absorption windows in the upper small intestine. However, immediate floating can only be achieved if the density of the device is low at the very beginning. Devices with an initially high density (which decreases with time) first settle down in the stomach and, thus, undergo the risk of premature emptying. Inherent low density can, for example, be provided by the entrapment of air or by the incorporation of low density materials or foam powder. This review explains briefly about factors affecting floating system, evaluation parameters and application of the system.
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