FORMULATION AND CHARACTERISATION OF SUSTAINED RELEASE CARVEDILOL TABLET FROM RESERVOIR PELLETS
AbstractSustained release Carvedilol tablets constituting reservoir pellets developed in this study is an attempt to investigate the effect of drug release from matrix. The sustained release Carvedilol tablets were prepared by using different combination with release modifier (ethyl cellulose 10 cps and Eudragit RS 100). Tablets containing disintegrant pellets (Crosspovidon) with active ingredient demonstrated a sustained rate of drug release. The Carvedilol tablets were prepared using different ratios of pellets. After 12 hours of dissolution study, Carvedilol release from the matrix systems were 92.35%, 92.37%, 95.25%, 93.26%, 92.87% and 90.4 2% from formulation F1, F2, F3, F4, F5 and F6 respectively. Formulation F2 (10% of Eudragit RS 100) exhibited 95.21% Carvedilol release in 12 h and satisfied all the physical evaluation parameters hence, considered as optimized batch. The Carvedilol sustained release F2 batch showed non-Fickian diffusion kinetics.
Article Information
18
626-34
783
1555
English
IJPSR
Amit M. Gupta* and U.D. Shivhare
Department of Pharmaceutics, Sharad Pawar College of Pharmacy, Nagpur, Maharashtra, India
amitmgupta31@gmail.com
01 August, 2015
25 September, 2015
13 November, 2015
10.13040/IJPSR.0975-8232.7(2).626-34
01 February, 2016
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