FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEX OF ACETYL SALICYLIC ACID (ASPIRIN) AND β- CYCLODEXTRIN BY SOLVENT EVAPORATION & ITS COMPARATIVE STUDY TO ASPIRIN ALONE
AbstractThe aim of present study was to determine whether pharmaceutical and pharmacological activity of aspirin would enhance in form of inclusion complex with β–cyclodextrin or not.Aspirin (Acetyl salicylic acid) a non steroidal anti-inflammatory drug, was formulated in to inclusion complex with β–cyclodextrin (β–CD) by solvent evaporation. The phase-solubility curve was AL type and Kst was found to be 127.8 M-1. FT-IR and microscopic examinatinos were revealed confirmation of inclusion formation. Solubility and permeability of aspirin was enhanced in presence of β–CD. Similarly the pharmacological activity i.e. analgesic and anti-inflammatory activity were also enhanced in presence of β – CD.
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