FORMULATION AND DEVELOPMENT OF LIPOSOMAL GEL FOR TOPICAL DRUG DELIVERY SYSTEM

Aim: The aims of this study were to develop liposome enriched Dexibuprofen liposomal hydrogels for topical delivery, perform in vitro release studies and in vivo permeation studies through mice/rat skin, and evaluate the efficacy of liposomal gels against inflammation induced rats. The purpose was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability and inflammation control for longer period from liposomal gels.

Method: Phosphatidylcholine, Cholesterol  and Dexibuprofen  were  dissolved  in chloroform/methanol  (2:1,  v/v)  mixture  and subsequently  transferred  into  a  pear-shaped  flask connected to a Rotavapor (Büchi- type). Rotary evaporation method was used for the formulation of liposomes.

 Result: liposome prepared was evaluated for particle size measurement, percent drug entrapment, diffusion study, skin permeation study and in vivo study. F-7 batch found to be optimized batch having particle size 5.40 µm, % drug entrapment 61.70, % CDR 75.35 %. Hence F-7 batch further evaluated for skin permeation study, skin deposition study, in vivo study and stability study.

Conclusion: The present study has been a satisfactory attempt to formulate and evaluate liposome of Dexibuprofen and liposomal gel with a providing sustained delivery of drug. From skin permeation study and in vivo study it was concluded that the prepared liposome of Dexibuprofen may prove to be potential candidate for safe and effective sustained drug delivery over an extended period of time which can reduce dosing frequency