FORMULATION AND DEVELOPMENT OF QUERCETIN AND MONOAMMONIUM GLYCYRRHIZINATE LOADED GEL FOR THE TREATMENT OF MOUTH ULCER DISEASE
AbstractDiagnosis of oral ulcerative lesions might be quite challenging. Oral ulcerative lesions were categorized into three major groups as acute, chronic, and recurrent ulcers. Helicobacter pylori (H. pylori) have been found in the oral cavity and stomach, and its infection is one of the most frequent worldwide. There is a close relation between H. pylori infection in the oral cavity and the stomach. H. pylori etiologic agent in recurrent apthous stomatitis, Canker sores. Quercetin inhibits the H. Pylori. Monoammonium glycyrrhizinate (MAG) was recogÂnized as a compound possessing antimicrobial properties; MAG tested many researchers using the agar diffusion method which, show significant antibacterial activities against gram-positive (Bacillus subtilis, Stap Hylococcus aureus) as well as gram-negative bacteria (Escherichia coli, PseuÂdomonas aeruginosa). The objective of the present investigation was to formulate and evaluate gel for mouth ulcer treatment of Quercetin and MAG. The concentration of carbopol p940 and propylene glycol were optimized using a central composite design for two factors. Formulations were evaluated for various parameters such as pH, viscosity, spreadability, drug content, cumulative drug diffusion, Texture analyzer, ex-vivo permeation, and mucoadhesion. The developed formulation was stable, safe, and effective for the treatment of mouth ulcer.
Article Information
52
1789-1798
917
1067
English
IJPSR
S. A. K. Shivaji * and R. V. Vaibhav
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.
akumarsalunkhe305@gmail.com
23 March 2020
22 June 2020
30 June 2020
10.13040/IJPSR.0975-8232.12(3).1789-98
01 March 2021