FORMULATION AND EVALUATION OF CLINDAMYCIN NANOSUSPENSION LOADED LYOPHILIZED POWDER FOR EFFICIENT TREATMENT OF AXILLARY OSMIDROSIS
AbstractThe aim of the present work was to develop clindamycin phosphate-loaded nanosuspension lyophilized powder for axillary osmidrosis caused by bacterial activity in apocrine glands. The formulation prepared using the solvent/antisolvent method included Eudragit L100, PVP K30, and Tween 80. Optimization via central-composite design (CCD) yielded formulation with a particle size of 179 nm and viscosity of 1.35 cps. Characterization confirmed favorable sedimentation volume, drug content and zeta potential with SEM revealing a spherical and porous structure. Lyophilization improved stability and permeability, and in-vitro studies demonstrated 24-hour drug release. Antibacterial testing showed good efficacy against Staphylococcus aureus indicating potential of clindamycin nanosuspension as a promising topical delivery system with enhanced efficacy.
Article Information
23
1039-1048
1318 KB
50
English
IJPSR
S. Hemanth Kumar, R. Suma *, Tanushree Chakraborty and K. Shailesh
Department of Pharmaceutics, Al-Ameen College of Pharmacy, Hosur Road, Bengaluru, Karnataka, India.
smrsumar@gmail.com
20 November 2024
18 December 2024
23 December 2024
10.13040/IJPSR.0975-8232.16(4).1039-48
01 April 2025
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